Background :
@EN Peripheral T-cell lymphomas(PTCL) frequently involve the skin and may occur as distinct clinicopathologic entities. However, clinicopathologic features of PTCLs involving the skin other than mycosis fungoides and Sezary syndrome have been
poorly
understood.
@ES Object :
@EN this study aimed to characterize the nature of PTCL involving the skin in the Korean population.
@ES Methods :
@EN twenty-three cases of PTCL which involved the skin were collected during period from July, 1991 to June, 1995. In addition to reviewing the clinical records and rdtine histologic slides of these cases, the immunohistochemical studies with
several
antibodies and in situ hybridization for Epstein-Barr virus9EBV) early RNAs were performed on selected cases.
@ES Result :
@EN We recognized five subtypes; mycosis fungoides, 5 cases, angiocentric T-cell lymphoma, 9 cases, diffuse large cell lymphoma, 4 cases(Ki-1 positive, 3 cases, Ki-1 negative, 1 case), subcutaneous T-cell lymphoma, 1 case, and unspecified PTCL. 4
cases.
Mycosis fungoides tends to involve papillary dermis with epidermotropism, where a angiocentric T-cell lymphoma and unspecified PTCL predominantly affect adnexae, venules, and subcutis. Among 9 cases of angiocentric T-cell lymphoma, EBV RNAs were
detected in 5 cases. In the prognostic point of view, mycosis fungoides and Ki-1 positive large cell lymphoma were notably favorable and angiocentric T-cell lymphoma, especially EBV related, was guarded.
@ES Conclusion:
@EN A variety of the distinct entities of PTCL which frequently involve the skin were identified in the Korean population. In addition to the clinicopathologic information. Immunophenotyping and EBV detection are thought to be crucial in
diagnosing
and
predicting the behavior of T-cell neoplasms. (Kor J Dermatol 1996;34(4) : 645~655)
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